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Diabetes Developments - A blog on latest developments in diabetes by David Mendosa

Omega-3 for Fatty Liver

March 3rd, 2010 · 7 Comments

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Fatty liver disease is one of the most common complications of diabetes. About 50 to 70 percent of those of us who have diabetes may have this potentially dangerous complication. But now we may have a way to treat it and stopping it from progressing to liver failure.

The first time I wrote about fatty liver was in 2005 when I had it myself. Fortunately, I have since been able to reverse it with diet and exercise.

My late wife Catherine wasn’t so fortunate. Her fatty liver progressed to liver failure, which led to her death in early 2007.

Catherine had type 2 diabetes and was seriously overweight, and neither of us knew at the time that this is the cause of most cirrhosis of the liver. We had always assumed that drinking too much alcohol was the cause — but she never drank any.

Since then I’ve learned a lot about the dangers and other causes of fatty liver disease. Just recently, in fact, Swedish researchers reported that people with nonalcoholic fatty liver disease have a higher overall mortality rate compared with the general population.

Israeli researchers reported in 2009 that drinking too much sweetened soda or too much fruit juice can cause fatty liver. They reported that people who drink more than about four cups daily of sweetened drinks were five times more likely to get a fatty liver. Sweetened sodas and natural fruit juices have a lot of sucrose (table sugar) or high-fructose corn syrup — and it doesn’t matter which, because both of them are about half glucose and half fructose. While we burn off the glucose quickly or store it in our brains and muscles, we process fructose through our liver, where the excess gets converted into fat in the cells of our liver.

Too late we learned that exercise and avoiding fructose might have prevented Catherine’s death. I wrote about “
Fatty Liver and Exercise” in 2008 and “A Short Walk Goes a Long Way” in 2009. I wrote about “The Trouble with Fructose” in 2007 and “More Trouble with Fructose” in 2008.

Now, we may have another way to reverse a fatty liver. This good news comes in a preliminary review article, “Omega-3 fatty acids — a promising novel therapy for non-alcoholic fatty liver disease (NAFLD).” Dr. Gail Masterton and two colleagues in Scotland’s University of Edinburgh just published this review in Alimentary Pharmacology & Therapeutics.

“Omega-3 fatty acids have proven benefits for hyperlipidaemia and cardiovascular disease,” they write, “and have recently been suggested as a treatment for NAFLD.” So they reviewed the evidence for omega-3 fatty acids in fatty liver disease and critically appraised the literature relating to human trials. While “clinical trials in human subjects generally confirm these findings,” they nevertheless have significant design inadequacies.

As usual, they found that we need more studies. But, their conclusion was that, “Omega-3 fatty acids are a promising treatment for NAFLD.”

My conclusion is “Why not?” After all, we already knew that increasing our omega-3 — and our balance of omega-3 to omega-6 fats — is something we need to do anyway. Just like getting more exercise may well be good for reversing fatty liver and much more, we damn well know that omega-3 is also good for lots more.

Ever here of “twofers”? One dictionary defines it as, “An offer, a deal, or an arrangement in which a single expense yields a dual return.” Omega-3, exercise, and avoiding fructose are — to coin a term — “Multifers.”

This is a mirror of one of my articles that Health Central published. You can navigate to that site to find my most recent articles.

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Posted in: Complications

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7 responses so far ↓

  • 1 alfredoe // Mar 4, 2010 at 4:26 pm

    Hi All. It is important to have in mind that there are certain conditions to get all the benefits fish oil can bring for a fatty liver.

    First, you need to take a minimum amount of fish oil, krill oil or cod liver oil at a certain frequency.

    There is not an establish amount of omega 3 fro any health benefit but I recommend to take at least 900 mg per day of omega 3 fats (close to 3.000 mg of fish oil), EPA plus DHA, per day.

    Also, you should lower your intake of omega 6 fats (mostly grains and grain oils) since omega 3 and omega 6 counteract each other in the body.

    Please read more at http://www.omega-3-fish-oil-wonders.com/fish-oil-benefits.html

    Best wishes,
    Alfredoe

  • 2 Greg F // Mar 18, 2010 at 6:45 pm

    Thanks for the web site. It sometimes feels a bit lonely dealing with diabetes. You have some great articles.

    Greg

  • 3 Donna // Apr 24, 2010 at 11:12 am

    Very well written so the common people can understand. I have been taking a combo of Omega 3-6-9 for a while with the intent of overall health. My last 3 blood tests show high liver counts, so I’ve been doing my homework. I am now concerned that adding more oils to the liver is counterproductive. It’s interesting to hear that we should cut back on Omega 6, as it can counter Omega 3.

    I have changed the way I eat dramatically over the last year (fresh vegtables, fruit, organic milk, etc) with no difference in blood counts or weight. I’ve finally tackled the sugar addiction…again to no results. I am not discouraged as I know it takes a while to heal the body. I do feel better and that is the bottom line. Your article is making me rethink the Omega 6 though .

  • 4 ray_fishoilvitamins // Aug 29, 2010 at 11:07 am

    Nice post. Sorry to learn about your wife. I can’t agree anymore on the combination of Diet and Exercise for good health.

    We need to strike a balance.

  • 5 Ben // Nov 6, 2010 at 5:51 am

    Lately there has been some talk about the engative effects that fish oil can have… The tests were done on mice… just a little heads up http://www.fishoilbenefit.net/news/fish-oil-increased-the-risk-of-colon-cancer-in-mice/

  • 6 Maneeshi Trivedi // Apr 12, 2014 at 4:36 am

    I would be interested in learning about the effects of Krill oil on fatty liver. 12 April 2014

  • 7 David Mendosa // Apr 12, 2014 at 4:42 pm

    Dear Maneeshi,

    I don’t know now whether krill oil will help. Please see my recent article at:

    http://www.healthcentral.com/diabetes/c/17/168446/managing-diabetes-strange-fat

    Namaste,

    David