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Diabetes Developments - A blog on latest developments in diabetes by David Mendosa

Day 4 ADA Chicago: Oral GLP-1

June 26th, 2007 · 2 Comments

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A pill form of GLP-1 may be coming. That’s the gist of a late breaking abstract at the American Diabetes Association’s annual convention that concluded at noon today. The embargo on this abstract expired a few minutes ago.

This can be big news, because the only GLP-1 now available, Byetta, requires injections twice a day. Still, it can be a long way from announcement to availability in your nearest drugstore.

The announcement is “a proof of concept study in healthy subjects” by seven researchers, including people associated with Emisphere Technology in Tarrytown, New York.

This company developed what it calls “the eligen technology,” that enables large molecules, like GLP-1, to cross membranes in the gut that they otherwise can’t. That’s why until now GLP-1 has to be taken by injection.

The abstract 03-LB, “Pharmacokinetics and Pharmacodynamic Effects of Oral Glp-1 and Pyy3-36,” isn’t online yet, so I can’t link it. But it concluded that the study “showed for the first time that satiety peptides such as GLP-1 and PYY3-36 can be delivered orally in humans.”

We don’t yet have any drugs based on the PYY 3-36 hormone, although Amylin Pharmaceutics says that it has a combination with pramlintide (Symlin) in Phase 1 trials for obesity.

But it could plays a critical role in decreasing our appetites, making us aware of feeling full. It has the opposite role of the hormone ghrelin, which increases our appetite.

All of these hormones, including insulin, might also be taken as a spray nasally. That’s what the first inhaled insulin, Exubera, is. But it’s not perfect, with potential lung problems and lesser bioavailability, as I wrote here when the Food and Drug Administration approved it in January.


Amylin Pharmaceuticals has reported that it has a nasal version of Byetta (exenatide) in Phase 1 trials. I’ve heard rumors that Amylin may also be working on an oral version of Byetta. So as soon as I read about the oral GLP-1 in development I called Alice Bahner Izzo, Amylin’s executive director for investor relations.

“Amylin hasn’t announced any work on an oral version of Byetta,” she told me.

That does not mean that the company is not working on it. It may be, since not everything the pharmaceutical companies are doing is public knowledge. But it certainly does look now like the biggest limitation with the hottest diabetes drug may be approaching resolution.

This is a mirror of one of my articles that Health Central published. You can navigate to that site to find my most recent articles.

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Posted in: Medication

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2 responses so far ↓

  • 1 Helena Galo // Jan 29, 2012 at 1:55 pm

    I’m really enjoying the theme/design of your blog. Do you ever run into any browser compatibility problems? A handful of my blog audience have complained about my site not working correctly in Explorer but looks great in Chrome. Do you have any tips to help fix this issue?

  • 2 David Mendosa // Jan 29, 2012 at 3:59 pm

    Dear Helena,

    I haven’t had any reports of compatibility problems. Personally, I use Chrome on my Macs.

    David

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