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Diabetes Developments - A blog on latest developments in diabetes by David Mendosa

Entries Tagged as 'Diabetes Medication'

Reduce Your Risk of Weight Loss Surgery

August 26th, 2016 · Comments Off

Do you have diabetes and a BMI above 35? If you do and decide to get bariatric surgery to help you manage your diabetes, it could be an excellent idea.

But will you to go to your nearest hospital for the procedure? That might not be the safest thing to do.

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Posted in: Diabetes Complications, Diabetes Medication

Does Weight Loss Surgery Keep Working for Diabetes Management?

August 24th, 2016 · Comments Off

Does your weight makes it difficult for you to manage your diabetes? Check out bariatric surgery, because it’s likely to help you to lose many pounds.

But how well will it help you manage your diabetes over the long term?

Until now, nobody knew the answer to this question. That’s why researchers have been studying a group of 120 adults with Type 2 diabetes at three teaching hospitals in the U.S. and one in Taiwan. Half of them got bariatric surgery, and half got intensive lifestyle medical management.

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Posted in: Diabetes Medication

Metformin Pro and Con

August 5th, 2016 · Comments Off

Metformin, the most popular diabetes medicine, figured in about 200 of the presentations at the recent annual convention of the American Diabetes Association. Two of these presentations show good news for its likely role in degenerative nerve disease and in dispelling concerns about its possible role in neuropathy. One presentation, however, brought some disturbing results, and the rest are of less interest to most people with diabetes.

This convention, which the ADA calls its 76th Scientific Sessions, attracted more than 16,000 attendees, including more than 13,000 professionals who went to New Orleans to see and hear almost 3,000 presentations about diabetes. I represented HealthCentral there.

Dr. Liu presents her poster on metformin

(Photo by David Mendosa)

A team of researchers from Tulane University’s School of Public Health and Tropical Medicine presented one poster and one oral presentation about metformin. Shuqian Liu, MD, presented the poster and told me that she designed both of these studies. The poster 570-P reported a retrospective study that examined the effect of high doses of metformin on neuropathy, a complication for 60 to 70 percent of people with diabetes.

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Posted in: Diabetes Medication

Vitamin D May Help Prevent Diabetic Retinopathy

June 27th, 2016 · Comments Off

If you have a low level of vitamin D, taking this inexpensive supplement may help you prevent diabetic retinopathy, one of the most serious complications of diabetes. This is the most common reason why some people with diabetes lose their vision.

A meta-analysis just presented at the Annual Scientific and Clinical Congress of the American Association of Clinical Endocrinologists, in Orlando, Florida, from May 25 to 29, found “a statistically significant association between diabetic retinopathy and vitamin D deficiency.” Three researchers presented their findings in an abstract, “The Relationship Between Vitamin D Deficiency and Diabetic Retinopathy: A Systematic Review and Meta-Analysis.” The Canadian Journal of Ophthalmology is expected to publish the full report soon, one of the study’s authors told me.

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Posted in: Diabetes Complications, Diabetes Medication

Diabetes Drug Might Stop Beta Cell Loss

June 24th, 2016 · Comments Off

When you have diabetes, you don’t have enough functioning beta cells. People with Type 1 diabetes have quickly lost almost all of these cells that make insulin, and if you have Type 2, you will typically experience a progressive decline in the number and size of your beta cells.

One type of diabetes drugs has been shown in animal studies to stop this progression. It may do this for humans too, but because the drug is so new researchers don’t know yet if it will work the same way for us.

The technical name for this drug class is a mouthful:  glucagon-like peptide-1 receptor agonists. Researchers often shorten it to GLP-1 receptor agonist or even to GLP-1. The newest brand of these drugs is Trulicity. The others that are available in the United States are Tanzeum, Victoza, Bydureon, and Byetta, which was the first.

These drugs to help us manage Type 2 diabetes have only been available for just over 10 years. While they haven’t been approved for people with Type 1, some of these people apparently benefit from using them too, when their doctors prescribe them off-label.

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Posted in: Diabetes Medication

Metformin: Best Oral Drug for Type 2 Diabetes

June 15th, 2016 · Comments Off

Metformin is the type of pill that your doctor should prescribe for you when you begin to manage type 2 diabetes. This is the key recommendation of a huge new meta-analysis. Of the six classes of oral drugs that the U.S. Food and Drug Administration approves when people take only one drug for diabetes, metformin ranks first in overall safety and effectiveness.

“We concluded that metformin looks better for cardiovascular mortality than sulfonylureas,” says lead author Nisa Maruthur, MD, of Johns Hopkins University School of Medicine in Baltimore. “It has a long-term safety profile. Metformin is weight neutral or helps people lose weight, and its gastrointestinal side effects are avoidable or tolerable. Its effect on A1C is similar to other medications.”

Until now, researchers didn’t have any firm evidence that one class of drugs was best at reducing cardiovascular risk — heart attacks and strokes. If you have uncontrolled blood glucose, this is your the most serious diabetes risk. But the researchers concluded that metformin reduces the relative risk of a patient dying from heart disease by about 30 to 40 percent compared to its closest competitor drug, the sulfonylurea class.

The Annals of Internal Medicine, a peer-reviewed journal of the American College of Physicians, just published the study online ahead of print as “Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes.” It is comprehensive meta-analysis of more than 200 studies with more than 1.4 million people with diabetes. Those studies made head-to-head comparisons of the six drug classes: metformin, sulfonylureas, thiazolidinediones, DPP-4 inhibitors, GLP-1 agonists, and SGLT-2 inhibitors.

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Posted in: Diabetes Medication

Berberine Is a Diabetes Drug in Disguise

May 27th, 2016 · 2 Comments

Berberine might be the best supplement that you can take to reduce your blood glucose. But first you need to consider the disadvantages of any supplement.

Berberine has apparently been an important herbal remedy in Chinese medicine for hundreds, if not thousands, of years. Now, it is becoming increasingly well known in the West.

Growing interest in berberine

The U.S. National Library of Medicine indexes about 4,000 studies in professional journals that include berberine. This is far more than the 800 on bitter melon and the 200 on gymnema sylvestre, which quite a few people have told me they use to manage their blood glucose. It’s clear that interest in berberine is growing fast: more than 1,500 of the 4,000 studies were published in the last five years.

But people use berberine for many conditions. Just 243 of these studies are about berberine and diabetes, and 79 of them are human studies (the others are studies of berberine in animals or in test tubes).

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Posted in: Diabetes Medication

You Can Use Metformin Even with Reduced Kidney Function

May 21st, 2016 · Comments Off

Metformin and 18 brand-name drugs that include it are safe for millions of people with diabetes who have reduced kidney function. This month, the U.S. Food and Drug Administration issued a drug safety communication that will let at least 2.5 million more Americans who have this disease use this diabetes drug.

In addition to metformin itself, which is a generic drug, it remains available as Glucophage, the original brand name. Other brands of metformin that the FDA’s decision affects include Actoplus Met, Avandamet, Glucovance, and Janumet.

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Posted in: Diabetes Medication

The High Cost of Diabetes

April 13th, 2016 · 1 Comment

Diabetes isn’t especially expensive because it causes nothing. But uncontrolled diabetes can be one of the most expensive diseases anybody can get.

The visits you have to make to your doctor, the blood glucose meters that you require to check your level, and the prescription medications that most people with diabetes need are only a small part of the economic costs of diabetes.  But all together, these essential components of diabetes management were just one-third of the estimated direct costs of diagnosed diabetes in 2012, the most recent year for which we have data.

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Posted in: Diabetes Medication

Start Taking Insulin Now

March 14th, 2016 · 11 Comments

You can avoid the worst consequences of diabetes if you take insulin soon after a doctor tells you that you have the disease, recent studies show. You can even drive your diabetes into remission and preserve the beta cell function of your pancreas that you otherwise could lose. When your beta cells don’t work well, it’s even harder to manage your diabetes.

While everyone who has type 1 diabetes has to take insulin, of course, only one-fourth of people with type 2 diabetes do so far, usually after years of failure on oral diabetes drugs. After you have tried one of them after another, and your blood glucose is still too high, people may have to go on insulin, although usually with reluctance. You still hear people with diabetes telling you with pride, “I don’t have to take insulin.”

Shape Up

Even worse is that some doctors even use it as a threat, saying something like, “If you don’t shape up, I’m going to make you inject insulin.” But by that time most of the beta cells of your pancreas that store and release your own body’s insulin into the bloodstream have also failed.

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Posted in: Diabetes Medication

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